UA Apollo x16D vs. RME Fireface UFX III vs. Focusrite Red 16Line

Specifications Comparison

Category UA Apollo x16D RME Fireface UFX III Focusrite Red 16Line
Approximate Price (Dec 2025) Essentials+ Edition: ~$2,999
Ultimate+ Edition: ~$3,999
~$3,199 ~$3,999
Computer Connection Thunderbolt 3 USB 3.0 Thunderbolt 3 + Pro Tools HD DigiLink (dual ports)
Analog I/O 18 x 20 (16 x 16 line-level via DB-25 + 2 XLR monitor outs; no mic preamps) 12 analog (4 mic/instrument via XLR/TRS combo + 8 line via TRS) + 2 headphone outs 18 x 20 (16 x 16 line-level via DB-25 + 2 XLR mic pres + 2 TRS monitor outs) + 2 headphone outs
Digital/Network I/O 16 x 16 Dante + stereo AES/EBU + Word Clock 64-channel MADI (optical/coaxial) + 16-channel ADAT (2 optical in/out) + stereo AES/EBU + Word Clock + 2 MIDI in/out 32 x 32 Dante (dual ports) + 16-channel ADAT (2 optical in/out) + 2-channel S/PDIF + stereo AES/EBU + Word Clock/Loop Sync
Total Channels (max) 18 in / 20 out (expandable to 64 x 64 via Dante with up to 4 units) 94 in / 94 out 64 in / 64 out
AD/DA Conversion 24-bit/192 kHz (133 dB dynamic range D/A) 24-bit/192 kHz 24-bit/192 kHz (118 dB dynamic range A/D, 121 dB dynamic range D/A)
DSP Processing HEXA Core for UAD plug-ins (over 200 available depending on edition) DSP for TotalMix FX (EQ, dynamics, reverb/delay on channels) Software-based mixer for low-latency monitoring
Latency & Drivers Low-latency via Thunderbolt and UAD Console software Low-latency drivers Low round-trip latency; host mode switching between Pro Tools HD and Thunderbolt
Key Features • Monitoring up to 9.1.6 formats
• Built-in talkback mic
• Plug-In Scenes recall via MIDI
• Monitor calibration integration with Sonarworks software
• Direct multitrack recording to USB drive
• DC-coupled outputs for CV/gate control
• Standalone operation as mixer/router
• Automatic gain setting for inputs
• 2 mic preamps with Air mode (high-frequency boost)
• Integration with Pro Tools HD without option cards
• Dual Thunderbolt ports for daisy-chaining
• Includes EQ and compression plug-ins
Best For Dante-based networked setups and immersive audio monitoring with plug-in processing Multitrack recording with multiple digital I/O formats and flexible routing Pro Tools HD workflows with Dante networking and low-latency monitoring
Universal Audio Apollo x16D rear panel Universal Audio Apollo x16D front panel

UA Apollo x16D

Thunderbolt 3 audio interface with Dante I/O.

RME Fireface UFX III front panel RME Fireface UFX III rear panel

RME Fireface UFX III

USB 3.0 audio interface with MADI I/O.

Focusrite Red 16Line front panel Focusrite Red 16Line rear panel

Focusrite Red 16Line

Thunderbolt 3 audio interface with DigiLink and Dante I/O.